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Interesting article on aromatization

Thread starter #1
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This is always a hot topic so I thought I would share this. Highlight what I thought was most interesting.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/#!po=46.8750

increases in total testosterone were associated with increases in E2 of proportionately lesser magnitude.

cross-sectional doubling of total testosterone was associated with an approximate 40% increase in mean E2 concentrations

Tl:dr e2 and test dose arent linearly related. Taking twice as much AI for 400mg as you do for 200mg is not a good idea.
 
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''The clinical consequences of higher E2 levels and higher E2:T ratios in older men remain poorly understood. In longitudinal studies in older men, higher E2 levels have been associated with adverse outcomes such as stroke (38) and cognitive decline (39). In cross-sectional studies, higher E2 levels have been associated with the increased risk of metabolic syndrome (40) and type 2 diabetes mellitus. Very low E2 levels have been associated with bone loss and fracture risk (41,42,43), insulin resistance and premature atherosclerosis (44), and higher risk of mortality in elderly men (45). Hence, too much as well as too little estrogen may be detrimental to the health in men. Further research is needed to elucidate the role of estrogen in men’s health, including defining thresholds beyond which E2 levels might be detrimental. ''

interesting
 
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''The clinical consequences of higher E2 levels and higher E2:T ratios in older men remain poorly understood. In longitudinal studies in older men, higher E2 levels have been associated with adverse outcomes such as stroke (38) and cognitive decline (39). In cross-sectional studies, higher E2 levels have been associated with the increased risk of metabolic syndrome (40) and type 2 diabetes mellitus. Very low E2 levels have been associated with bone loss and fracture risk (41,42,43), insulin resistance and premature atherosclerosis (44), and higher risk of mortality in elderly men (45). Hence, too much as well as too little estrogen may be detrimental to the health in men. Further research is needed to elucidate the role of estrogen in men’s health, including defining thresholds beyond which E2 levels might be detrimental. ''

interesting
"Associated with" is a bit of a non-statement as far as im concerned.

They need to study all of this more.
 
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