Oh shit.....Big M droppin mother fukin knowledge bombs lolI did not say cure Alzheimer, as we cannot cure it yet once established. but indirectly, I would say a strong/leading preventative in development of the chronic illness.
I honestly don't understand how you can sit there and still believe that IF does not aid in the improvement and correction of heart disease through the direct improvement of insulin resistance.
I'll expand below.
I do have access and have read the two controlled 10 group rat study, and honestly it does have great data, albeit unnecessary to prove my statements.
By comparing two isolated groups of bio-identical rats, they concluded that:
1) Alzheimers reduced bone mineral density in the spine and femur, intermittent fasting reduced that.
2) Abdominal fat mass reduced in IF group (Why is abdominal relevant? Insulin resistance and fatty liver)
3) IF decreased food intake without changing energy expenditure (caloric/nutrient efficiency, improved insulin resistance & glucose oxidation)
4) IF increased fat oxidation as a fuel source compared to the increasing glucose oxidation in the Alzheimer's group.
5) IF restored insulin resistance in the fasting state and decreased serum glucose level. As a result, oral glucose was administered and the IF group increased insulin secretion for fuel oxidation.
6) Alzheimers deteriorated short and spatial memory function, IF prevented it.
7) Cortisol was elevated by Alzheimers, IF decreases it.
8) IF improved dyslipidemia and liver damage index (dyslipidemia is the abnormal amount of lipids in the blood)(aka the beginning of heart disease).
9) IF improved low-density lipoprotein cholesterol and serum triglyceride levels, meanwhile alzheimers damages them.
So right out the gate, I picked out 9 positive scientifically proven benefits of IF pertaining to cognitive function, deterioration and energy metabolism in a study based off of 20 rats. Useless right? on rats? Rubbish.
Why do we use rats? 95% of all lab animals are rodents. convenience, price, maintenance, adaptation to new environments, quick reproduction, short lifespan. Allowing us to see long term studies in several generations of inbred bio-identical rats, in a relatively short period of time. Rats are used as models because their genetic, biological and behavioral characteristics closely resemble those of humans.
Scientists can even breed genetically-altered transgenic mice that carry genes similar to those that carry human diseases.
Currently rats are used as models for nearly everything in medical literature, if not indefinitely, at least deemed safe first before human studies. To neglect data on Alzheimers with data based on rats, one also must neglect existing literature on Hypertension, Diabetes, Cataracts, Obesity, Seizures, Respiratory problems, Deafness, Parkinsons, Cystic Fibrosis, HIV, AIDs, Heart disease, Muscular dystrophy and spinal cord injuries.
You go to the doctor for medicines for treating various illnesses, all of which are initially or currently tested on rodents.
To say that data on rats is trivial is just ignorant, I don't see you volunteering to have amyloids of Alzheimer's disease infused into your hippocampus for scientific research on degenerative brain disease.
That is my stance on that study and the efficacy of rats as medical trials.
How Intermittent Fasting prevents Alzheimer's disease
As for the mechanism on how Alzheimers develops? It's relatively simple.
Alzheimer's and Dementia are essentially the brain being starved of fuel over an extended period of time.
Glucose is the primary fuel source of the brain, but there are certain factors that can prevent the absorption of glucose.
This specific case has to do with the blood brain barrier and the insulin connection.
Insulin allows glucose to be absorbed in cells, brain and muscle.
You know what insulin resistance is.
Despite how much insulin is being pumped out by the pancreas, the brain is not utilizing the insulin. This further worsens the condition by signalling to the pancreas to produce even more insulin because there isn't enough for the brain to absorb fuel.
As a result, the brain starts to develop a protein fibrous tissue known as an amyloid.
People with amyloids & Alzheimers are proven to have a low glucose metabolism.
A symptom of this is craving sweets, because the brain is not getting enough glucose due to insulin resistance.
(Ironic that long term diabetics typically develop memory/cognitive issues and eventually Alzheimers/Dementia).
Every time you eat, you spike insulin.
You know how to reduce insulin right? Exercise, reduce carbs, less meals, less meal frequency. Intermittent Fasting.
Therefore Intermittent fasting indirectly improves our chances at avoiding and preventing cognitive & memory impairment, Alzheimers and Dementia.
This is further proven by the development of a new product, Intranasal Insulin. This is a nasal spray insulin that connects to nerve fibers in the Olfactory Bulb, bypassing the blood brain barrier and going directly to the brain. This new nasal spray insulin has shown major improvements in memory. There's lots of literature and studies on this product pertaining to memory and alzheimers if you're curious.
Minor to moderate memory decline can be reversed and improved. The Hippocampus is the part of the brain responsible for motivation, emotion, learning and memory. The Hippocampus is one of the only areas in the brain where Neurogenesis can occur, which is the development of new nerve cells. Intermittent fasting is the leading cause of increased BDNF (Brain-Derived Neurotrophic Factor), which strengthens brain signaling and synapses. Intermittent fasting also stimulates the production of stem cells, which can be utilized in the development of new brain tissue.
How Intermittent Fasting prevents Heart disease
What is heart disease?
Generally refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack, chest pain (angina) or stroke.
Other heart conditions, such as those that affect your heart's muscle, valves or rhythm, are also considered forms of heart disease.
LDL is a lipoprotein that transports cholesterol. The body needs cholesterol to rebuild cells. Whenever you damage your cells, such as gym, LDL brings cholesterol to the cell. The cholesterol is removed from the LDL to repair the cells and the LDL then returns to the Liver to be recycled (normal situation). HDL brings the cholesterol from your cell or arteries back to the Liver, very important to clear bad cholesterol (small dense).
Ultimately what happens is an impaired digestive system compromises the gut bacteria/immune barrier. the immune cells start to kill gut bacteria which releases part of the bacterial membrane known as endotoxin. endotoxin then gets into your blood stream and binds to LDL. Any time you have inflammation (continual scheduled eating of refined carbs & sugars), you increase your LDL production. Endotoxins are very damaging to the system and can eventually cause sepsis and death. The body has a response mechanism of soaking up the endotoxin cholesterols so it doesn't damage your tissue and organs.
The problem is when the Endotoxins bind to the LDL, they use the cholesterol receptor. As the LDL returns to the Liver for recycling, it can no longer transport cholesterol because the endotoxin is taking up the receptor already. So the body has no choice but to continually have these LDL proteins with endotoxins circulating in our blood stream.
Endotoxins are a signal for your immune cells to attack and remove the bacteria. But since it's cholesterol, the immune cells cannot kill it. So the immune cells now secrete pro-inflammatory cytokines, which recruit more, which eventually forms what's known as a plaque. Now the small LDL with the endotoxins has a bunch of immune cells attached to it, so it's now a small dense particle and it's stuck in your circulation.
Eventually the plaque ruptures on the damaged arterial lining and forms a blood clot, limiting or blocking flow entirely, resulting in stroke and/or death. This process is commonly referred to as Atherosclerosis.
Interesting, but what does that have to do with Insulin or Intermittent Fasting?
IF limits many risk factors for the development and occurrence of cardiovascular diseases.
By affecting the biochemical transformations of lipids, it decreases body mass and has a positive influence on lipid profiles by reducing the concentration of total cholesterol, triglycerides and LDL.
IF inhibits the development of atherosclerotic plaque by reducing the concentration of inflammatory markers.
IF diet alters the levels of aidpokines (+adiponectin, -leptin, -resistin) which inhibits the adhesion of endotoxin cholesterol cells to vascular cells, further reducing the formation of plaque and limiting the collection and migration of cells to the arterial membrane.
Since IF causes an increase in BDNF (explained above under alzheimers prevention section), it lowers the systolic and diastolic blood pressure by activating the parasympathetic system. BDNF causes acetylcholine to be released by the vagus nerve to reduce the frequency of heart contractions.
IF has been documented in obese and diabetics to improve glucose metabolism and insulin sensitivity.
IF limits cardiac hypertrophy.
IF reduces stress and inflammation in the body.
So in conclusion, heart disease is caused by obvious factors such as:
Blood pressure, cholesterol, obesity, diabetes, exercise and stress.
Every single one of these problems can be prevented and/or corrected by intermittently fasting, thus preventing heart disease/atherosclerosis/cardiovascular disease and even Alzheimer's disease.
Fasting & Alzheimer's Disease sources:
20 rat Alzheimer's study
Connection of brain insulin resistance in Alzheimer's patients associated with IGF-1 resistance, IRS-1 dysregulation and cognitive decline
Brain Insulin Resistance and Deficiency as Therapeutic targets in Alzheimer's Disease.
Brain Insulin Resistance identified as possible new link between Alzheimer's Disease, Diabetes
How does brain insulin resistance develop in Alzheimer's Disease
Midlife Insulin Resistance affects brain Function (connection to increased risk of Alzheimer's with Type 2 Diabetic Patients)
Insulin in the Brain: Its pathophysiological implications for states related with central insulin resistance, type 2 diabetes and alzheimer's disease.
Sugar for the brain: the role of glucose in physiological and pathological brain function
Fasting & Heart Disease sources:
Intermittent Fasting in Cardiovascular Disorders - An Overview
Intermittent Fasting and Human Metabolic Health
Fasting: Molecular Mechanisms and Clinical Applications
Increased gut microbiota diversity after fasting
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota